Slade had shoulder surgery after the summer tour to New Zealand and has not played for Exeter yet this season, while Sale's Curry made his return from a concussion lay-off in Friday's win over Newcastle.

Mitchell's absence means Ben Spencer, Jack van Poortvliet and Harry Randall are the three named scrum-halves.

Sale's George Ford will continue his rehabiltation from a torn quad muscle as part of the squad, with Marcus Smith and Fin Smith the other specialist stand-offs.

Fin Baxter (Harlequins), Ollie Chessum (Leicester), Dan Cole (Leicester), Luke Cowan-Dickie (Sale), Chandler Cunningham-South (Harlequins), Ben Curry (Sale), Tom Curry (Sale), Theo Dan (Saracens), Trevor Davison (Northampton), Alex Dombrandt (Harlequins), Ben Earl (Saracens), Charlie Ewels (Bath), Ellis Genge (Bristol), Jamie George (Saracens) Nick Isiekwe (Saracens), Maro Itoje (Saracens), Joe Marler (Harlequins), George Martin (Leicester), Will Stuart (Bath), Sam Underhill (Bath).

Elliot Daly (Saracens), Immanuel Feyi-Waboso (Exeter), Tommy Freeman (Northampton), George Furbank (Northampton), Ollie Lawrence (Bath), Alex Lozowski (Saracens), Luke Northmore (Harlequins), Harry Randall (Bristol), Tom Roebuck (Sale), Henry Slade (Exeter), Ollie Sleightholme (Northampton), Fin Smith (Northampton), Marcus Smith (Harlequins), Ben Spencer (Bath), Freddie Steward (Leicester), Jack van Poortvliet (Leicester)

Rehabilitation: George Ford (Sale)

Not considered for selection: Alex Coles (Northampton), Joe Cokanasiga (Bath), Fraser Dingwall (Northampton), Alex Mitchell (Northampton), Will Muir (Bath), Max Ojomoh (Bath), Raffi Quirke (Sale), Bevan Rodd (Sale).